24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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![[D-Trp<sup>8</sup>]-?-<wbr/>MSH (trifluoro<wbr/>acetate salt)](https://www.bertin-bioreagent.com/wp-content/uploads/2024/07/14037.png "[D-Trp<sup>8</sup>]-?-<wbr/>MSH (trifluoro<wbr/>acetate salt)")
From €92.00 €78.20
[D-Trp8]-?-MSH is a melanocortin receptor 3 (MC3R) agonist and an analog of ?-melanocyte-stimulating hormone (?-MSH).{63354} It selectively induces cAMP accumulation in cells expressing MC3R over cells expressing MC4R or MC5R (EC50s = 0.33, 100, and 82 nM, respectively, for the human receptors). In vivo, [D-Trp8]-?-MSH (162 nmol/kg, i.v.) reduces the incidence of ventricular tachycardia, ventricular fibrillation, and death in a rat model of myocardial ischemia-reperfusion injury.{63356} It also inhibits urate-induced chemokine (C-X-C) motif ligand 1 (CXCL1) release and peritoneal polymorphonuclear leukocyte accumulation in recessive yellow (e/e) mice with a non-functional MC1R.{63355}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C74H99N21O16S • XCF3COOH |
| Smiles | O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC(CNC([C@H](CCSC)NC([C@H](C(C)C)NC([C@@H](N)CC2=CC=C(O)C=C2)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O |
| Molecular weight | 1570,8 |
| Custom code | 3504.00 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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