D-<em>erythro</em> Lysosphingo<wbr/>myelin (d18:1)

D-erythro Lysosphingomyelin (d18:1)

CAT N°: 10007947
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136.00 115.60

D-erythro Lysosphingomyelin is a bioactive sphingolipid.{37413} It is an agonist of sphingosine-1-phosphate receptor 1 (S1P1), S1P2, and S1P3 (EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors). D-erythro Lysosphingomyelin is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50 = ~35 nM).{59108} Levels of D-erythro lysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.{18804,59109} As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1318]

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