Cytarabine 5?-mono<wbr/>phosphate

Cytarabine 5?-monophosphate

CAT N°: 36496
Price:

From 66.00 56.10

Cytarabine 5?-monophosphate (ara-CMP) is an active metabolite of the nucleoside analog cytarabine (Item No. 16069).{62684} It is formed from cytarabine by deoxycytidine kinase.{48672} ara-CMP is incorporated into DNA by DNA polymerase ?, which slows the rate of DNA synthesis by approximately 2,000-fold in a cell-free assay.{62685} It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae when used at a concentration of 15 mM.{62686} ara-CMP (3.5-75.1 mg/kg) improves survival in an L1210 murine leukemia model.{62687}

We also advise you