Cyclic AMP

Cyclic AMP

CAT N°: 18820
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Cyclic AMP (cAMP) is a central second messenger in cell signaling, propagating signals from receptors to downstream pathways. It is generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.{16830} cAMP activates protein kinase A and the exchange proteins activated by cAMP (Epac1 and Epac2), which are nucleotide exchange factors for the Rap family of GTPases.{20516,23361} cAMP is degraded to AMP by cyclic nucleotide phosphodiesterases.{22521}

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