24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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CpdA is a non-steroidal selective glucocorticoid receptor modulator.{33998} It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus.{33998,33996} It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF-?B and subsequent cytokines through transrepression.{33997} Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone (Item No. 11015) that were either higher (4-fold, IC50 = 6.4 nM and 25.9 nM, respectively, in L929sA cells) or lower (63-fold, Kd = 81.8 nM and 1.29 nM, respectively, in BWTG3 cells) in whole cell binding assays.{33996,33997}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 100 mg, 25 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 14593-25-0 |
| Molecular formula | C11H14ClNO2 • HCl |
| Smiles | CC(OC1=CC=C(C(Cl)CNC)C=C1)=O.Cl |
| Molecular weight | 264,1 |
| Custom code | 2922.19 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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