Corynoxeine

Corynoxeine

CAT N°: 31403
Price:

From 140.00 119.00

Corynoxeine is an alkaloid that has been found in Uncaria and has diverse biological activities.{57268,57269,57270,45602} It inhibits LPS-induced production of nitric oxide (NO) in primary rat microglia (IC50 = 15.7 µM).{57268} Corynoxeine (5-50 µM) inhibits PDGF-BB-induced ERK1/2 activation in, and proliferation of, rat aortic vascular smooth muscle cells (VSMCs).{57269} It inhibits histamine release from LAD 2 mast cells induced by compound 48/80 (Item No. 22173) when used at concentrations ranging from 25 to 200 µM.{57270} In vivo, corynoxeine (0.5, 2.5, and 5 mg/kg) reduces compound 48/80-induced local anaphylaxis and mast cell degranulation in mouse hind paws. Corynoxeine (30 and 100 mg/kg) also reduces methamphetamine-induced hyperlocomotion in mice.{45602}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (?E,1?R,6?R,7?S,8?aS)-6′-ethenyl-1,2,2?,3?,6?,7?,8?,8?a-octahydro-?-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1?(5?H)-indolizine]-7?-acetic acid, methyl ester
  • Correlated keywords
    • Corynoxein ?18 Rhyncophylline PDGFBB ERK 1/2 LAD2 rhynchophylla
  • Product Overview:
    Corynoxeine is an alkaloid that has been found in Uncaria and has diverse biological activities.{57268,57269,57270,45602} It inhibits LPS-induced production of nitric oxide (NO) in primary rat microglia (IC50 = 15.7 µM).{57268} Corynoxeine (5-50 µM) inhibits PDGF-BB-induced ERK1/2 activation in, and proliferation of, rat aortic vascular smooth muscle cells (VSMCs).{57269} It inhibits histamine release from LAD 2 mast cells induced by compound 48/80 (Item No. 22173) when used at concentrations ranging from 25 to 200 µM.{57270} In vivo, corynoxeine (0.5, 2.5, and 5 mg/kg) reduces compound 48/80-induced local anaphylaxis and mast cell degranulation in mouse hind paws. Corynoxeine (30 and 100 mg/kg) also reduces methamphetamine-induced hyperlocomotion in mice.{45602}

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