Combreta<wbr/>statin A1

Combretastatin A1

CAT N°: 19750
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128.00 108.80

Combretastatin A1 is a cis-stilbene originally isolated from C. caffrum that inhibits microtubule assembly (ID50 = 2 µM) by binding to the colchicine (Item No. 9000760) binding site on ?-tubulin.{38547,38548} It inhibits proliferation of hepatocellular carcinoma (IC50s = 9.2-728.2 nM) and other carcinoma cell lines (IC50s = 12.2-2,247 nM).{38548} Combretastatin A1 increases apoptosis of HepG2 cells in a GSK3?-dependent manner by decreasing the levels of MCL-1 and ?-catenin. It inhibits tumor growth in a hepatocellular carcinoma mouse xenograft model when administered at doses of 2 or 4 mg/kg for 4 weeks. It also enhances the effects of carboplatin (Item No. 13112), paclitaxel (Item No. 10461), and cisplatin (Item No. 13119) in murine models of cancer.{38549,38550} Combretastatin A1 decreases functional vascular volume within hours in a well-vascularized murine colon adenocarcinoma model.{38551}

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