Colivelin

Colivelin

CAT N°: 24239
Price:

From 365.00 310.25

Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity.{41809,41811} It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid ? (1-43) (A?43) when used at concentrations of 10 and 100 fM, respectively.{41809} Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory.{41811} Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of A?25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).{41810}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-?-glutamyl-L-isoleucyl-L-?-aspartyl-L-leucyl-L-proline
  • Correlated keywords
    • STAT-3 V642IAPP
  • Product Overview:
    Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity.{41809,41811} It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid ? (1-43) (A?43) when used at concentrations of 10 and 100 fM, respectively.{41809} Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory.{41811} Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of A?25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).{41810}

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