Cobicistat

Cobicistat

CAT N°: 23433
Price:

From 55.00 46.75

Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors).{41224} It is selective for CYP3A over other CYP isomers (IC50 = >25 ?M for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 ?M) or affect HIV replication in MT-2 cells (EC50 = >30 ?M). Formulations containing cobicistat have been used to slow the metabolism of concomitantly administered protease inhibitors in the treatment of HIV.{41225}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3R,6R,9S)-12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester
  • Correlated keywords
    • GS9350 HIV1 MT2
  • Product Overview:
    Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors).{41224} It is selective for CYP3A over other CYP isomers (IC50 = >25 ?M for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 ?M) or affect HIV replication in MT-2 cells (EC50 = >30 ?M). Formulations containing cobicistat have been used to slow the metabolism of concomitantly administered protease inhibitors in the treatment of HIV.{41225}

We also advise you