CMS121

CMS121

CAT N°: 27085
Price:

From 48.00 40.80

CMS121 is a substituted quinoline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.{47397,47398,47400} It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay.{47397} CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively.{47398} It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-?, caspase-1, and inducible nitric oxide synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.{47400}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[4-(cyclopentyloxy)-2-quinolinyl]-1,2-benzenediol
  • Correlated keywords
    • CMS 121 neuro-protective antiinflammatory anti-oxidative reno-protective HT 22 hippo-campal PC 12 N 9 TE AC TNF? caspase1 i NOS SAMP 8 lipopolysaccharide
  • Product Overview:
    CMS121 is a substituted quinoline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.{47397,47398,47400} It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay.{47397} CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively.{47398} It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-?, caspase-1, and inducible nitric oxide synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.{47400}

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