CMPF-<wbr/>d<sub>5</sub>

CMPF-d5

CAT N°: 9001871
Price:

From €129.00 €109.65

CMPF-d5 contains five deuterium atoms at the 2, 2′, 3, 3, and 3 positions. It is intended for use as an internal standard for the quantification of CMPF (Item No. 10007133) by GC- or LC-mass spectrometry. Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.{13184} CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).{13104,13105} CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.{13105} Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.{13105}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-(2-carboxyethyl)-4-methyl-5-(propyl-2,2′,3,3,3-d5)furan-3-carboxylic acid
  • Correlated keywords
    • standards deuterateds LC/MS GC-MS LC-MS MS mass spectrometry deuterium references thyroxines T3 T4 furan fatty acids inactive primary secreted products thyroid glands converted active hormones triiodothyrodinine enzymes 5′-deiodinase albumin-bound furanoids accumulates serums uremic patients inhibits cellular transport subsequent deiodination displaces competitive binding molecules acidic drugs free oleic endocrinology
  • Product Overview:
    CMPF-d5 contains five deuterium atoms at the 2, 2′, 3, 3, and 3 positions. It is intended for use as an internal standard for the quantification of CMPF (Item No. 10007133) by GC- or LC-mass spectrometry. Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.{13184} CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).{13104,13105} CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.{13105} Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.{13105}

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