From €348.00 €295.80
Clusterin is a secreted heterodimeric glycoprotein.{19214} It is proteolytically processed to remove a signal peptide and cleave the α and β chains.{19214,58474} This cleavage creates small- and medium-sized isoforms found in the nucleus or cytosol and mitochondria, respectively, and a large-sized isoform composed of α- and β chains linked via disulfide bonds near the center that is secreted outside the cell.{58474} Clusterin is ubiquitously expressed in tissues and found in physiological fluids. It is a multifunctional protein involved in a wide range of processes, including immune modulation, autophagosome formation, apoptosis, and extracellular matrix remodeling, among others.{58475} Clusterin is upregulated by cellular stress and acts as an extracellular chaperone and scavenger to prevent protein aggregation. SNPs in CLU, the gene encoding clusterin, are associated with a higher rate of cognitive decline in patients with mild cognitive decline or Alzheimer’s disease.{58476} Clusterin is also associated with inflammatory and cardiovascular diseases, where it has either protective or detrimental effects.{58474} Cayman’s Clusterin (human, recombinant) protein consists of 438 amino acids and has a calculated molecular weight of 51.5 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 37 and 39 kDa for the cleaved β and α chains, respectively.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg, 50 µg |
|---|---|
| Shipping | dry ice |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Purity | ≥92% estimated by SDS-PAGE |
| Custom Code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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