Clozapine N-<wbr/>oxide (hydro<wbr/>chloride)

Clozapine N-oxide (hydrochloride)

CAT N°: 25780
Price:

From 102.00 86.70

Clozapine N-oxide is a major metabolite of clozapine (Item No. 12059) and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively).{27576,35354} It prevents action potential firing in cultured hippocampal neurons transiently expressing hM4D receptors.{35354} Clozapine N-oxide increases glutamate in the nucleus accumbens core and inhibits cue-induced reinstatement of cocaine-seeking behavior in rats transfected with hM3Dq DREADD receptors.{42492}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, dihydrochloride
  • Correlated keywords
    • 34233-69-7 hM1 hM2 hM3 hM4 hM5 hM-1 2 3 4 5
  • Product Overview:
    Clozapine N-oxide is a major metabolite of clozapine (Item No. 12059) and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively).{27576,35354} It prevents action potential firing in cultured hippocampal neurons transiently expressing hM4D receptors.{35354} Clozapine N-oxide increases glutamate in the nucleus accumbens core and inhibits cue-induced reinstatement of cocaine-seeking behavior in rats transfected with hM3Dq DREADD receptors.{42492}

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