Clodronate (sodium salt hydrate)

Clodronate (sodium salt hydrate)

CAT N°: 16134
Price:

From 55.00 46.75

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18285} Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption.{24450} Clondronate is metabolized intracellularly to a ?-?-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.{26453} Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.{26454}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • P,P’-(dichloromethylene)bis-phosphonic acid, disodium salt, tetrahydrate
  • Correlated keywords
    • bisphosphonates bones resorption osteoclasts inhibitors osteoporosis cancers macrophages apoptosis 10596-23-3 22560-50-5 non-nitrogenous non nitrogenous nonnitrogenous treatments metabolic metabolism metabolized diseases binds hyrdroxyapatite crystals affinity growths resorptions intracellular ?-?-methylene ? ? methylene ??-methylene analogs ATP cytotoxic cytotoxicity liposomes liposome-encapsulated encapsulated encapsulates biological selective selectively depletes depletion depleted macrophage-like like macrophagelike cells bone-related research immunology inhibitors inhibitions inhibiting signals signaling phosphonic acids disodium salts tetrahydrates clodronates
  • Product Overview:
    Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18285} Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 µM, inhibiting their growth (IC50 = 1.34 µM) and bone resorption.{24450} Clondronate is metabolized intracellularly to a ?-?-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.{26453} Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.{26454}

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