Cl-Necrostatin-1

Cl-Necrostatin-1

CAT N°: 11656
Price:

From 74.00 62.90

Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1).{20736} It inhibits RIPK1 activity when used at concentrations of 0.3, 3, and 30 µM. It also inhibits TNF-?-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling.{20737,62489} Cl-Necrostatin-1 (2 µl of a 4 mM solution, i.c.v.) reduces infarct size when administered pre- and post-occlusion, or post-occlusion only, in a mouse model of middle cerebral artery occlusion (MCAO).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo-4-imidazolidinone
  • Correlated keywords
    • RIPK 7ClNec1 ClNec1 ClNec Nec1 Nec1f
  • Product Overview:
    Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1).{20736} It inhibits RIPK1 activity when used at concentrations of 0.3, 3, and 30 µM. It also inhibits TNF-?-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling.{20737,62489} Cl-Necrostatin-1 (2 µl of a 4 mM solution, i.c.v.) reduces infarct size when administered pre- and post-occlusion, or post-occlusion only, in a mouse model of middle cerebral artery occlusion (MCAO).

We also advise you