CK-666

CK-666

CAT N°: 29038
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From 48.00 40.80

CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex (IC50s = 4, 17, and 5 ?M for the human, bovine, and S. pombe complexes, respectively, in an actin polymerization assay).{27974} It binds at the Arp2/3 interface, stabilizing the inactive conformation of the complex.{53317} CK-666 (40 ?M) inhibits actin comet tail formation around intracellular L. monocytogenes in infected SKOV3 cells.{27974} It induces actin remodeling, inhibits lamellipodia formation, and reduces the motility rate in M-1 epithelial cells when used at a concentration of 200 ?M.{34274} CK-666 (100 ?M) impairs long-term fear memory formation in rats when microinjected into the lateral amygdala.{53318}

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