Ciprofibrate

Ciprofibrate

CAT N°: 18515
Price:

From 55.00 46.75

Ciprofibrate is an agonist of peroxisome proliferator-activated receptor ? (PPAR?; EC50 = 0.9 µM in a transactivation assay).{61725} It is selective for PPAR? over PPAR? and PPAR? at 300 µM.{7009} Ciprofibrate (250 µM) induces cell cycle arrest at the G2/M and S phases in Fao rat, but not HepG2 human, hepatocellular carcinoma cells.{61726} It decreases fasting plasma levels of triglycerides and increases fasting plasma glucose levels in the apolipoprotein CIII transgenic mouse model of hypertriglyceridemia when administered at a dose of 10 mg/kg.{29848} Formulations containing ciprofibrate have been used in the treatment of hypertriglyceridemia.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-propanoic acid
  • Correlated keywords
    • 128660-46-8 ciprol lipanor modalim win-35,833 win35833 win-35833 win35,833 PPAR peroxisome proliferator-activated receptor ? PPAR? PPARa PPAR? PPARg PPAR-? PPAR-g PPAR-a PPAR-?
  • Product Overview:
    Ciprofibrate is an agonist of peroxisome proliferator-activated receptor ? (PPAR?; EC50 = 0.9 µM in a transactivation assay).{61725} It is selective for PPAR? over PPAR? and PPAR? at 300 µM.{7009} Ciprofibrate (250 µM) induces cell cycle arrest at the G2/M and S phases in Fao rat, but not HepG2 human, hepatocellular carcinoma cells.{61726} It decreases fasting plasma levels of triglycerides and increases fasting plasma glucose levels in the apolipoprotein CIII transgenic mouse model of hypertriglyceridemia when administered at a dose of 10 mg/kg.{29848} Formulations containing ciprofibrate have been used in the treatment of hypertriglyceridemia.

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