Cipargamin

Cipargamin

CAT N°: 30678
Price:

From 123.00 104.55

Cipargamin is an antimalarial agent.{59375,59376,18552} It inhibits the Na+-ATPase activity of wild-type or mutant P. falciparum P-type ATPase (PfATP4; IC50s = 12.3-13.9 and 21.1-32.5 nM, respectively, in P. falciparum membranes).{59375} Cipargamin is active against the P. falciparum chloroquine-sensitive strain NF54 and chloroquine-resistant strain K1 (IC50s = 0.5 and 0.6 nM, respectively).{59376} It reduces parasitemia and increases survival in a mouse model of P. berghei infection when administered at doses of 10, 30, and 100 mg/kg.{18552}

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