Cinnarizine-d<sub>8</sub>

Cinnarizine-d8

CAT N°: 33977
Price:

166.00 141.10

Cinnarizine-d8 is intended for use as an internal standard for the quantification of cinnarizine (Item No. 21001) by GC- or LC-MS. Cinnarizine is a calcium channel inhibitor and histamine H4 receptor antagonist (Ki = 142 nM).{54940,54941,32995} It inhibits L- and T-type calcium channels in isolated guinea pig atrial cells in a voltage-dependent manner.{54940} Cinnarizine inhibits L-type calcium currents in isolated guinea pig type II vestibular hair cells (IC50 = 1.5 µM). In vivo, cinnarizine (10 mg/kg) inhibits ethanol-induced gastric ulcer formation in rats.{54942} Formulations containing cinnarizine have been used in the treatment of nausea and vomiting due to vertigo, Meniere’s disease, or chemotherapy.

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