Cimetidine-d<sub>3</sub>

Cimetidine-d3

CAT N°: 29050
Price:

468.00 397.80

Cimetidine-d3 is intended for use as an internal standard for the quantification of cimetidine (Item No. 18743) by GC- or LC-MS. Cimetidine is a histamine H2 receptor antagonist (Ki = 0.6 ?M).{30325} It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 ?M). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 ?M).{30545} In vivo, it inhibits histamine-induced gastric acid secretion in gastric fistulae and Heidenhain pouches in dogs (ED50 = 1.88 ?mol/kg, p.o.). Cimetidine (20 mg/kg per day) also reduces tumor growth and neovascularization in a CMT93 colon cancer mouse syngeneic model.{47643}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-cyano-N”-methyl-d3-N’-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-guanidine
  • Correlated keywords
    • NSC 335308 NSC335308 SKF 92334 SKF92334 deuterated deuterium GCMS LCMS d-3 Acibilin Acinil Biomet Cimal Cimetag Cimetum Dyspamet Edalene Eureceptor Fremet Gastromet Histodil Peptol Tagamet Tamagret Tametin Tratul Ulcedin Ulcedine Ulcerex Ulcerfen Ulcimet Ulcofalk Ulcomedina Ulcomet Ulhys H-2 c-AMP neo-vascularization
  • Product Overview:
    Cimetidine-d3 is intended for use as an internal standard for the quantification of cimetidine (Item No. 18743) by GC- or LC-MS. Cimetidine is a histamine H2 receptor antagonist (Ki = 0.6 ?M).{30325} It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 ?M). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 ?M).{30545} In vivo, it inhibits histamine-induced gastric acid secretion in gastric fistulae and Heidenhain pouches in dogs (ED50 = 1.88 ?mol/kg, p.o.). Cimetidine (20 mg/kg per day) also reduces tumor growth and neovascularization in a CMT93 colon cancer mouse syngeneic model.{47643}

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