Chlortetracycline

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
• Correlated keywords
  • 96066-24-9 96968-60-4 98271-27-3 103651-17-8 856305-72-1 1236363-43-1 A-Mycin acronize PD aureocarmyl aureociclin aureocina aureomicina aureomycin aureomykoin aurofac 10 biomycin a CTC centraureo chloratet 50 chlorocyclinum trichlortetracycline chlorotetracycline chrusomykine chrysomykine chrysomykine duomycin flamycin orospray uromycin tri Streptomyces Enterobacter Escherichia Klebsiella Morganella Staphylococcus chlortetracyclin anti-biotic Aerobacter Diplococcus proteus
• Product Overview:
  Chlortetracycline is a broad-spectrum antibiotic originally isolated from S. aureofaciens.{36361,36363} It inhibits growth of both Gram-positive and Gram-negative bacteria at a range of 0.1-100 ?g/ml against A. aerogenes, D. pneumoniae, E. coli, K. pneumoniae, P. morganii, and several species of Haemophilus, Neisseria, Salmonella, and Staphylococcus.{36363} Chlortetracycline protects mice from infection by various strains of S. aureus with protective doses (PD50s) of 0.2-7.5 mg/kg, and from infection by E. coli (PD50 = 3 mg/kg) and K. pneumoniae (PD50 = 75 mg/kg).{36362} It acts by inhibiting protein synthesis, and it binds to a single site on the 30S ribosome subunit.{36361} Chlortetracycline is an ionophore and is selective for calcium over sodium, potassium, magnesium, strontium, and barium.{36364} It transports calcium from an aqueous phase into an organic phase environment or into multilamellar vesicles. Chlortetracycline is also a fluorescent dye that can be used to monitor calcium flux.{36365}