Chlorothalonil

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile
• Correlated keywords
  • 1 1000 101963-73-9 1192 15 164 164SA 216082-57-4 231 2787 2787WP 342632-51-3 37223-69-1 404 404D 462093-27-2 500-SC 500SC 50SC 54 54D 54DB 6F 720 750 750PM 75WP 801 96 960 Agronil Barrack Blotch Bravo Bravonil Busan Chloronil Chlorothalonil Chlorthalonil Clortosip D DAC Daconil Dacosoil Dakoflo DB F Fongil Forturf Fungitrol Guarant Gwarant Hortyl Kabiguard Kavach L M M1 M15 Marincide Microban mildewcide N N96 NexGen Nopcocide Nuocide Optimist PI PM SA SC SD SD404 Sweep Termil Tetrachlorobenzene Thalonil TPN Tuff-Brite TuffBrite Ultrex Vanox Weather Stik Weatherstik WP YS Candida Colletotrichum Staphylococcus Bacillus Escherichia Pseudomonas Phytophthora
• Product Overview:
  Chlorothalonil is a broad-spectrum organochlorine fungicide that forms adducts with glutathione (GST; Item No. 10007461) and cysteine residues on enzymes leading to GST depletion and enzyme deactivation, respectively.{41822} In vitro, it inhibits the growth of C. albicans and C. orbiculare fungi, S. aureus and B. cereus Gram-positive bacteria, and E. coli and P. aeruginosa Gram-negative bacteria (MICs = 0.7, 5, 1.3, 0.7, 0.5, and 1.7 µg/ml, respectively).{41823,41824} In vivo, chlorothalonil (100 µg/ml) completely inhibits the growth of P. infestans, the tomato late blight pathogen, on tomato plants.{41825} It is toxic to aquatic organisms, including species of fish, crustaceans, molluscs, and algae with tenth percentile of toxicity values of 25.23, 40.59, 0.69, and 3.94 µg/L, respectively, as well as to other aquatic invertebrates.{41826} Chlorothalonil is carcinogenic in animal models and induces neoplasms in the forestomach and kidneys of rats when administered at a dose of 3.8 mg/kg per day, but it is not genotoxic.{41827} Formulations containing chlorothalonil have been used as fungicides in agriculture.