Chlormethiazole (hydrochloride)

Chlormethiazole (hydrochloride)

CAT N°: 33437
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From 55.00 46.75

Chlormethiazole is a potentiator of GABAA receptors.{60313} It potentiates GABA-induced currents in L-M(TK-) cells expressing ?1?1?2 or ?1?2?2 subunit-containing GABAA receptors with EC50 values of 0.8 and 3.4 µM, respectively. Chlormethiazole protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 130.8 mg/kg).{60314} It reduces infarct volume in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO).{60315} Formulations containing chlormethiazole have been used in the treatment of acute alcohol withdrawal.

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