Chloram<wbr/>phenicol Succinate

Chloramphenicol Succinate

CAT N°: 25453
Price:

From 146.00 124.10

Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol.{36717} It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro.{36718} Chloramphenicol succinate reduces human leukocyte migration in vitro.{36719} In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively.{36720} Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury.{36721} Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • butanedioic acid, mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester
  • Correlated keywords
    • 53906-65-3 CAPS chloromycetin chronicin foam kemicetine levomycetin paraxin anti-biotic Escherichia
  • Product Overview:
    Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol.{36717} It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro.{36718} Chloramphenicol succinate reduces human leukocyte migration in vitro.{36719} In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively.{36720} Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury.{36721} Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.

We also advise you