CHIR98014

CHIR98014

CAT N°: 15578
Price:

From 122.00 103.70

The two isoforms of glycogen synthase kinase 3, GSK3? and GSK3?, constitutively phosphorylates and inactivates glycogen synthase, preventing glycogen synthesis.{19045} They also phosphorylate proteins that are relevant to Alzheimer’s disease and osteogenesis.{25567,25565,25566} CHIR98014 is a reversible, cell-permeable inhibitor of GSK3? and GSK3? (IC50 = 0.65 and 0.58 nM, respectively).{19045} It is inactive against a series of other serine/threonine or tyrosine kinases.{19045} Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals.{19045} CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.{22495,25566}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine
  • Correlated keywords
    • diabetes metabolic syndromes Alzeimer’s diseases CHIRs CHIR-98014 GSKs GSK3? GSK3a GSK3alpha GSK3.alpha. GSK-3? GSK-3a GSK-3alpha GSK-3.alpha. GSK3? GSK3b GSK3beta GSK3.beta. GSK-3? GSK-3b GSK-3beta GSK-3.beta. GSK-3 GSK3 glucose disposal diabetic tau phosphorylation Wnt signaling osteogenesis 556813-39-9
  • Product Overview:
    The two isoforms of glycogen synthase kinase 3, GSK3? and GSK3?, constitutively phosphorylates and inactivates glycogen synthase, preventing glycogen synthesis.{19045} They also phosphorylate proteins that are relevant to Alzheimer’s disease and osteogenesis.{25567,25565,25566} CHIR98014 is a reversible, cell-permeable inhibitor of GSK3? and GSK3? (IC50 = 0.65 and 0.58 nM, respectively).{19045} It is inactive against a series of other serine/threonine or tyrosine kinases.{19045} Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals.{19045} CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.{22495,25566}

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