Chicago Sky Blue 6B

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 6,6?-[(3,3?-dimethoxy[1,1?-biphenyl]-4,4?-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid, tetrasodium salt
• Correlated keywords
  • 3841-14-3 CSB 6B 6 B CaMKPN PP 2C PP2 C 2 Hepa RG Airedale FFD Amanil FF Atlantic Resin Fast LLGG Atul FB Direct Azine Brilliant Azocard Belamine Benzanil Benzo 6BS Brasilamina 6BA CF 6BACF CI24410 Calcodur 6GFL 6G Calcomine Chloramine Chlorantine 5GL Chlorazol Chrome Leather Cresotine Diacotton Diaphtamine Diazine Diazol Pure Diphenyl Azure Bright MFF Green Shade Enianil Fastusol L 8GU L8GU Fenamin Fixanol Hispamin Incomine Ink Japanol 6BKX Kayaku Mitsui Naphtamine DD NCI9617 Niagara Nyanza Orbamin Oxamine Paper Paramine Phenamine Pheno 6BX Greenish Pyrazol 2F VP Shikiso Sirius Supra Solar 4G Tertrodirect Vegentine CSW Vondacel
• Product Overview:
  CSB6B is a dye and derivative of glutamate with diverse biological activities.{59218,59219,59220,59221,59222} It is a competitive inhibitor of vesicular glutamate transporters (vGLUTs), inhibiting glutamate uptake by rat brain synaptic vesicles (Ki = 0.19 µM) but not by synaptosomes when used at a concentration of 0.1 mM.{59218} CSB6B is also an inhibitor of calcium/calmodulin-dependent protein kinase phosphatase (CaMKP) and its nuclear isoform CaMKP-N (IC50s = 4.1 and 1 µM, respectively).{59219} It is selective for CaMKP and CaMKP-N over protein phosphatase 2C (PP2C) and calcineurin, which it inhibits by less than 10 and 20%, respectively, at 10 µM. CSB6B inhibits sodium/taurocholate cotransporting polypeptide (NTCP; IC50 = 7.1 µM) and reduces hepatitis B virus (HBV) and hepatitis delta virus (HDV) infection in HepaRG cells when used at a concentration of 17 µM.{59220} Intracerebroventricular administration of CSB6B (0.5 µg) inhibits inflammatory pain in mice, reducing writhing induced by acetic acid and nociceptive behavior during the second phase of the formalin test without affecting locomotor activity.{59221} It also reduces thermal hyperalgesia in the complete Freund’s adjuvant test but not thermal pain in the hot plate test. CSB6B has also been used as a counterstain to reduce background autofluorescence in immunohistochemical preparations.{59222}