Chelidonic Acid

Chelidonic Acid

CAT N°: 31324
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From 66.00 56.10

Chelidonic acid is a pyran that has been found in C. majus and has diverse biological activities.{61073,61074,61075} It inhibits rat brain glutamate decarboxylase (Ki = 1.2 ?M).{61074} Chelidonic acid (20 mg/kg per day) reduces serum IL-6 and TNF-? levels, colonic COX-2 and prostaglandin E2 (PGE2; Item No. 14010) levels, and the disease activity index score in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS; Item No. 23250).{61073} It inhibits ovalbumin challenge-induced decreases in spleen IFN-? levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis when administered at a dose of 2 mg/kg.{61075}

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