Chebulagic Acid

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • ?-D-glucopyranose, cyclic 3,6-[(1R)-4,4′,5,5′,6,6′-hexahydroxy[1,1′-biphenyl]-2,2′-dicarboxylate] 1-(3,4,5-trihydroxybenzoate), cyclic 2?2:4?1-ester with (2S)-2-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid
• Correlated keywords
  • 19293-38-0 Terminalia COX1 COX2 5LO 15LO NF?B RAW264.7 HCT 15 COLO205 DU145 K 562 3T3L1 anti-viral MDAMB231
• Product Overview:
  Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities.{47061,47062,47063,47065,47064} It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 ?M, respectively) as well as ?-glucosidase and 15-LO (IC50s = 0.05 and 24.9 ?M, respectively).{47061,47062} Chebulagic acid inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-1, COX-2, and 5-LO protein levels, production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-?B in RAW 264.7 macrophages in a concentration-dependent manner.{47063} It inhibits the growth of HCT15, COLO 205, MDA-MB-231, DU145, and K562 cancer cells (GI50s = 20.3, 18, 26.2, 28.54, and 30.66 ?M, respectively).{47061} Chebulagic acid increases insulin-stimulated glucose uptake in 3T3-L1 adipocytes by 10.2-, 13.8-, and 16.6-fold when used at concentrations of 10, 50, and 100 ?M, respectively.{47065} It also scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 1.4 ?M) and exhibits antiviral activity against cytomegalovirus, hepatitis C virus, dengue virus, measles virus, and respiratory syncytial virus in vitro (EC50s = 25.5, 12.16, 13.11, 34.42, and 0.38 ?M, respectively).{47061,47064}