α-CGRP (rat) (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-seryl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanylglycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-serylglycylglycyl-L-valyl-L-valyl-L-lysyl-L-?-aspartyl-L-asparaginyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-?-glutamyl-L-alanyl-L-phenylalaninamide, cyclic (2?7)-disulfide, trifluoroacetate salt
• Correlated keywords
  • 83651-90-5 204656-20-2 ?CGRP RAMP-2 RAMP3 ET1
• Product Overview:
  ?-Calcitonin gene-related peptide (?-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.{41395} It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin (Item Nos. 24409 | 24410), and adrenomedullin.{38633} ?-CGRP binds selectively to heterotrimeric complexes of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins RAMP 1 or 3 (RAMP1 and 3; IC50s = 7 and 23 nM, respectively) over a complex of CRLR and RAMP2 (IC50 = >1,000 nM).{41531} It binds to rat brain and spleen membrane preparations (IC50s = 3.9 and 3.5 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2? (PGF2?; Item No. 16010; IC50s = 0.23 and 2.24 nM, respectively).{38809,41528} In vivo, ?-CGRP (0.01-3,000 ng/kg) decreases mean arterial blood pressure (MABP) and increases pial arteriole (PA) and middle meningeal artery (MMA) diameters in rats with closed cranial windows.{41532} It induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 (ET-1; Item No. 24127) in vivo in hamster cheek pouch at a concentration of 39.8 pM.{41529}