CGP 37157

CGP 37157

CAT N°: 15611
Price:

From 217.00 184.45

CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 ?M in isolated mitochondria).{25544} It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum.{25544} CGP 37157 is commonly used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis.{25548,25547} CGP 37157 inhibits sodium-dependent calcium efflux via the mitochondrial exchanger NCLX in a variety of cell types (IC50 = 5 ?M).{25545,25546}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
  • Correlated keywords
    • 164075-?13-?2 inhibitors inhibits inhibitions ions channels blockers mitochondrial biology intracellular signaling CGPs 37157 CGP37157 CGP-37157 benzothiazepine selective sodium-calcium sodium calcium exchanger NCLX exchangerNCLX cytoplasmic homeostasis cells types
  • Product Overview:
    CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 ?M in isolated mitochondria).{25544} It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum.{25544} CGP 37157 is commonly used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis.{25548,25547} CGP 37157 inhibits sodium-dependent calcium efflux via the mitochondrial exchanger NCLX in a variety of cell types (IC50 = 5 ?M).{25545,25546}

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