CGP 36742

CGP 36742

CAT N°: 35495
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225.00 191.25

CGP 36742 is an antagonist of GABAB receptors (IC50 = 36 µM).{61872} It is selective for GABAB over a panel of 11 receptors, including GABAA, at 1 mM. CGP 36742 (3 mg/kg) reduces paired-pulse inhibition of the late inhibitory postsynaptic potential (IPSP) in CA1 pyramidal neurons in rats. It increases latency to step-down in a passive avoidance test in mice in a dose-dependent manner.{61873} CGP 36742 (10 and 30 mg/kg) decreases immobility time in the forced swim test in mice.{61874}

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