Cefuroxime-d<sub>3</sub>

Cefuroxime-d3

CAT N°: 31163
Price:

439.00 373.15

Cefuroxime-d3 is intended for use as an internal standard for the quantification of cefuroxime (Item No. 23627) by GC- or LC-MS. Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 ?g/ml).{40366} Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis.{40367} It is resistant to hydrolysis by bacterial ?-lactamases, increasing its efficacy against ?-lactamase-producing Gram-negative bacteria.{40368} Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED50 values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively.{40369} Formulations containing cefuroxime have been used to treat urinary tract infections.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (6R,7R)-3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-((methoxy-d3)imino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Correlated keywords
    • deuterated deuterium GCMS LCMS Escherichia Haemophilus Neisseria Proteus Streptococcus viridans streptococci
  • Product Overview:
    Cefuroxime-d3 is intended for use as an internal standard for the quantification of cefuroxime (Item No. 23627) by GC- or LC-MS. Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 ?g/ml).{40366} Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis.{40367} It is resistant to hydrolysis by bacterial ?-lactamases, increasing its efficacy against ?-lactamase-producing Gram-negative bacteria.{40368} Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED50 values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively.{40369} Formulations containing cefuroxime have been used to treat urinary tract infections.

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