€598.00 €508.30
Cyclic dinucleotide phosphodiesterase (CdnP) is a soluble phosphodiesterase involved in regulating cyclic dinucleotide signaling during intracellular infections of M. tuberculosis.{36095} It is composed of an N-terminal Asp-His-His (DHH) domain and a C-terminal DHH-associated (DHHA1) domain that catalyze the hydrolysis of cyclic dinucleotides. CdnP hydrolyzes a variety of cyclic dinucleotides, including cyclic di-AMP (Item No. 17753), cyclic di-GMP (Item No. 17144), and 2?3?-cGAMP (Item No. 19887), which decreases their recognition by the stimulator of interferon genes (STING), a key mediator in the host innate immune response.{36905,33472,36906} Knockout of the gene encoding CdnP, CnpB, increases the production of IFN-? in isolated mouse bone marrow-derived macrophages (BMDMs) infected with CnpB-/- M. tuberculosis, as well as decreases pulmonary and splenic bacterial burden and increases survival in CnpB-/- M. tuberculosis-infected mice.{36097} Cayman’s CdnP (Mycobacterium tuberculosis strain ATCC 25618H37Rv recombinant) protein contains N-terminal Trx- and His-tags followed by a thrombin cleavage site and an S-tag followed by an enterokinase cleavage site.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 50 mM HEPES, pH 8.0, with 150 mM sodium chloride |
| Purity | ≥70% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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