CDDO-<wbr/>TFEA

CDDO-TFEA

CAT N°: 90001845
Price:

From 92.00 78.20

The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA is a trifluoroethylamide derivative of CDDO with enhanced ability to cross the blood brain barrier. It has been shown to enhance Nrf2 expression and signaling in various models of neurodegeneration, including those that simulate multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.{25928,25926,25925} CDDO-TFEA induces apoptosis of Ewing’s sarcoma and neuroblastoma cell lines, preventing colony formation at IC50 values ranging from 85-170 nM.{25927}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide
  • Correlated keywords
    • neuroprotection anti-inflammatory anti inflammatory antiinflammatory multiple sclerosis cytokines triterpenoids Nrf2 antioxidants oleanolic acids experimental autoimmune encephalomyelitis EAE myelin amyotrophic lateral sclerosis ALS Huntington’s Huntingtons Huntington disease neuroblastoma neurodegeneration apoptosis CDDOs TFEA CDDOTFEA signals transductions oxidative injury inhibitors inhibits inhibitions inflammation cancers steroids oxysterols RTAs 404 RTA404 RTA-404 TP500 TPs 500 Tp-500 synthetics anti-cancer anticancer neuroprotective blood brains blood-brains barriers ewing’s sarcoma ewing ewings neurosciences CDDO trifluoroethyl amides CDDO-tfea
  • Product Overview:
    The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA is a trifluoroethylamide derivative of CDDO with enhanced ability to cross the blood brain barrier. It has been shown to enhance Nrf2 expression and signaling in various models of neurodegeneration, including those that simulate multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.{25928,25926,25925} CDDO-TFEA induces apoptosis of Ewing’s sarcoma and neuroblastoma cell lines, preventing colony formation at IC50 values ranging from 85-170 nM.{25927}

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