€615.00 €522.75
CD5 is a type I transmembrane glycoprotein receptor and member of the scavenger receptor cysteine-rich (SRCR) superfamily.{59697} It is composed of three extracellular cysteine-rich domains, a transmembrane region, and a cytoplasmic tail containing an imperfect immunoreceptor tyrosine-based activating motif (ITAM). CD5 is expressed at differing levels on mature CD4+ and CD8+ T cells and thymocytes, and at lower levels on B1a cells and B cell chronic lymphocytic leukemia (B-CLL) cells.{59698} It acts a negative regulator of T cell signaling, despite the presence of an ITAM, and has a role in promoting the survival of thymocytes and mature T cells. CD5+ B cells are at their highest levels during development, lowest during early adulthood, and increase in middle-to-late adulthood, a change that correlates with an increased incidence of B-CLL and mantle cell lymphoma (MCL).{59699} CD5+ B cells primarily have a follicular mantle phenotype and produce low affinity polyreactive antibodies. CD5 expression on T cells protects against experimental autoimmune encephalomyelitis (EAE) in mice, but the levels of CD5+ B cells are increased in patients with systemic lupus erythematosus (SLE).{59700,59701} CD5 has a complex role in cancer, with high levels of CD5 on tumor-infiltrating T cells (TILs) protecting TILs from apoptosis, but reduced CD5 levels on TILs enhancing CD8+ T cell-mediated lysis of malignant cells.{59700} CD5 has commonly been used as a marker of T cells, B1a cells, and B-CLL cells.{59698} Cayman’s CD5 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of human CD5 |
| Clone | RM314 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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