€615.00 €522.75
CD38, also known as ADP-ribosyl cyclase 1, is a single-chain type II transmembrane glycoprotein with enzymatic activity and cell surface receptor functions that has roles in calcium signaling and immunomodulation.{59815,59816,59817} It is composed of a C-terminal catalytic domain, which can be orientated towards the extracellular or intracellular environment, a transmembrane segment, and a short N-terminal cytoplasmic tail, which interacts with the tyrosine kinase Lck.{59815,59818} CD38 expression is induced by cytokine, interferon, or endotoxin stimulation in a variety of immune cells, including T cells, B cells, granulocytes, and natural killer (NK) cells, as well as malignant plasma cells, and predominantly localizes to lipid rafts.{59815,59817,59816} It is also found in the nucleus and mitochondrial membrane, as well as in the cytoplasm.{59815} CD38 regulates calcium signaling by catalyzing the formation of the intracellular calcium mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP).{59819} It is a receptor for CD31, an adhesion molecule expressed by endothelial cells, and associates with a variety of signaling complexes, such as CD3/T cell receptor and CD19/CD21/B cell receptor complexes.{59817,59815} CD38 protein expression is increased on plasma cells isolated from patients with multiple myeloma.{59820} Cayman’s CD38 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide corresponding to residues near the C-terminus of human CD38 |
| Clone | RM388 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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