CD28 (C-Term) Rabbit Monoclonal Antibody

Territorial Availability: Available through Bertin Technologies only in France

• Correlated keywords
  • CD-28 80 CTLA4 B-7 a b c IL2 IFN? 28a 28b 28c PI3-K PI-3K RM-404 TP 44
• Product Overview:
  CD28 is a glycoprotein and member of the CD28/B7 family of co-stimulatory receptors that promotes T cell activation.{52543} Alternative splicing of CD28 produces one full-length long isoform, CD28 long, and three short isoforms, CD28a, CD28b, and CD28c.{52544} CD28 long exists as a membrane-bound homodimer and contains a leader peptide, an extracellular immunoglobulin variable (IgV) domain that interacts with the co-stimulatory molecules CD80 (Item No. 32013) or CD86 and a cytoplasmic tail that mediates the association with the signal transduction enzyme PI3K and is critical for T cell activation.{52543,52545} CD28a, CD28b, and CD28c contain truncated extracellular or transmembrane domains and exist as soluble monomers (CD28a) or membrane-bound homodimers (CD28b and CD28c).{52544} CD28 is constitutively expressed on the surface of T cells, upregulated by antigen-presenting cells (APCs) displaying MHC-bound antigen, and downregulated after T cell activation.{52546,52547} CD28 competes with CTLA-4 (Item No. 32009), an inhibitor of T cell activation also expressed on T cells, for binding to CD80 or CD86, promoting T cell activation by inducing the production of cytokines, such as IL-2 and IFN-?, and decreasing the T cell receptor activation threshold.{52546} Genetic deletion of Cd28 abolishes cellular infiltration and bone erosion in the joints and decreases serum levels of anti-collagen-IgG in a mouse model of collagen-induced arthritis.{52548} CD28 levels are decreased on plasma cells isolated from patients with multiple myeloma and this decrease is associated with disease progression and poor prognosis.{52549} CD28 SNPs have been found in individuals with sporadic breast cancer.{52550} Cayman’s CD28 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.