CCS-1477

CCS-1477

CAT N°: 34546
Price:

From 74.00 62.90

CCS-1477 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases.{62373} It selectively binds to p300 and CBP over bromodomain-containing protein 4 (BRD4; Kds = 1.3, 1.7, and 222 nM, respectively). CCS-1477 inhibits the proliferation of OPM-2 multiple myeloma cells (GI50 = 5 nM). It induces tumor regression in MOLM-16 acute myeloid leukemia (AML) and OPM-2 mouse xenograft models when administered at a dose of 20 mg/kg.

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