From €302.00 €256.70
Chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES, is a pro-inflammatory chemokine and member of the CC subfamily of chemokines.{57372} It is composed of an unstructured N-terminal region, a flexible loop, a 310-helix, three strands of an antiparallel ?-sheet, and a single C-terminal ? helix.{57373} It is expressed in T cells, platelets, macrophages, tubular epithelial cells, synovial fibroblasts, and endothelial cells, as well as some tumor cells.{57372} It functions as a monomer or various oligomers and interacts with the G protein-coupled receptors (GPCRs) chemokine (C-C motif) receptor 1 (CCR1), CCR3, CCR4, CCR5, and GPR75 to activate cell signaling in an oligomerization state-dependent manner. It also interacts with the non-signaling receptors ACKR1, ACKR2, and CCRL2. CCL5 functions as a chemoattractant of immune cells that predominantly express CCR5, such as activated T cells and monocytes, as well as those expressing CCR1 and CCR3, including macrophages and eosinophils, respectively.{57374} Production of CCL5 is induced in response to viral infections, including HIV, rhinoviruses, respiratory syncytial virus (RSV), coronaviruses, and influenza.{57375} CCL5 expression positively correlates with disease progression in patients with breast cancer.{57372} Cayman’s CCL5/RANTES (human, recombinant) protein consists of 69 amino acids and has a calculated molecular weight of 8 kDa.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg, 20 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Host | E. coli |
| Custom code | 3504.00 |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Purity | ≥95% estimated by SDS-PAGE |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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