CCCP

CCCP

CAT N°: 25458
Price:

From 48.00 40.80

CCCP is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential.{39958} It inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM, respectively.{39959} CCCP inhibits activation of stimulation of interferon genes (STING), decreasing the expression of downstream STING targets, including IFN-?, TBK1, and IRF3 when used at a concentration of 50 µM in RAW 264.7 cells.{39960} It induces mitochondrial fission in a manner dependent on the GTPase Drp1. CCCP (4 mg/kg) increases body temperature as well as left ventricular systolic and diastolic dimensions and decreases fractional shortening in rats.{39961} It also increases myocardial glucose and fatty acid uptake in rats.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[2-(3-chlorophenyl)hydrazinylidene]-propanedinitrile
  • Correlated keywords
    • 81693-28-9 208707-97-5 IFN? TBK-1 IRF-3 Drp-1 NSC88124
  • Product Overview:
    CCCP is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential.{39958} It inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM, respectively.{39959} CCCP inhibits activation of stimulation of interferon genes (STING), decreasing the expression of downstream STING targets, including IFN-?, TBK1, and IRF3 when used at a concentration of 50 µM in RAW 264.7 cells.{39960} It induces mitochondrial fission in a manner dependent on the GTPase Drp1. CCCP (4 mg/kg) increases body temperature as well as left ventricular systolic and diastolic dimensions and decreases fractional shortening in rats.{39961} It also increases myocardial glucose and fatty acid uptake in rats.

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