CAY10774

CAY10774

CAT N°: 32569
Price:

From 48.00 40.80

CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 15 nM in a homologous time-resolved fret (HTRF) assay).{59853} It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50 = 6.6 µM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+ and CD8+ T cells co-cultured with aAPCs.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (S)-1-(3-bromo-4-((2-bromo-[1,1′-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
  • Correlated keywords
    • CAY-10774 PD1 PDL1 coculture CD
  • Product Overview:
    CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 15 nM in a homologous time-resolved fret (HTRF) assay).{59853} It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50 = 6.6 µM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+ and CD8+ T cells co-cultured with aAPCs.

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