CAY10744

CAY10744

CAT N°: 29802
Price:

From 85.00 72.25

CAY10744 is a topoisomerase II-? poison.{50794} It inhibits topoisomerase II-? by 78.9% when used at a concentration of 20 µM. CAY10744 is selective for topoisomerase II-? over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 µM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 µM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-(2-chlorophenyl)-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol
  • Correlated keywords
    • CAY 10744 II? HCT 15 T47 D T-47D 47 DU 145 MDAMB231 MDAMB MB231
  • Product Overview:
    CAY10744 is a topoisomerase II-? poison.{50794} It inhibits topoisomerase II-? by 78.9% when used at a concentration of 20 µM. CAY10744 is selective for topoisomerase II-? over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 µM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 µM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.

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