24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Isolated neonatal rat cardiomyocytes, which spontaneously beat in culture, are used to evaluate the antiarrhythmic effects of polyunsaturated fatty acids (PUFA).{21675} In this model, the ?-3 PUFA eicosapentaenoic acid (EPA, 3-10 ?M) reduces the contraction rate of cells, indicating a positive antiarrhythmic effect.{21675} Cytochrome P450 metabolites of EPA are more potent, with 17,18-epoxyeicosatetraenoic acid (17,18-EET) reducing contractions at 30 nM.{18672} CAY10665 is a bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM.{19905} This disubstituted oxamide represents a stable analog of 17,18-EET which may be used to study the mechanism of regulation of cardiomyocyte contractility by EPA metabolites.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg, 25 µg, 50 µg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 1235543-17-5 |
| Molecular formula | C19H34N2O4 |
| Smiles | O=C(C(NC)=O)NCCCC/C=CCCCCCCCCCC(O)=O, O=C(C(NC)=O)NCCCC/C=CCCCCCCCCCC(O)=O, O=C(C(NC)=O)NCCCC/C=CCCCCCCCCCC(O)=O, O=C(C(NC)=O)NCCCC/C=CCCCCCCCCCC(O)=O |
| Molecular weight | 354,5 |
| Custom code | 2922.19 |
| Formulation | A solution in ethanol |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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