CAY10650

CAY10650

CAT N°: 10743
Price:

From 97.00 82.45

Cytosolic phospholipase A2? (cPLA2?) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.{14663} CAY10650 is a highly potent (IC50 = 12 nM) cPLA2? inhibitor.{18732} It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.{18732} The phase I metabolite of this compound, CAY10641 (Item No. 10662), is also available.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3-(2-methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
  • Correlated keywords
    • cPLA2? cPLA2 inhibitors inflammation anti-inflammatory dermatitis metabolite phospholipase cytosolic prostaglandins PGs leukotrienes synthesis 10662 CAY-10650 CAY10641 CAY-10641
  • Product Overview:
    Cytosolic phospholipase A2? (cPLA2?) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.{14663} CAY10650 is a highly potent (IC50 = 12 nM) cPLA2? inhibitor.{18732} It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.{18732} The phase I metabolite of this compound, CAY10641 (Item No. 10662), is also available.

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