CAY10626

CAY10626

CAT N°: 13838
Price:

From 157.00 133.45

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3′ hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3, important second messengers that modulate the activity of downstream targets Akt and mTOR.{8039} Aberrant PI3K/Akt is associated with many human cancers. CAY10626 is a potent, dual PI3K?/mTOR inhibitor with IC50 values of 0.9 and 0.6 nM for the two respective kinases.{18031} In a tumor cell growth inhibition assay, CAY10626 demonstrates IC50 values of 50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3K? and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed.{18031}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[2-(dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]-benzamide
  • Correlated keywords
    • PI3K? mTOR cancers signal transduction inhibitors inhibits inhibition phosphatidylinositol 3-kinase PtdIns PIs
  • Product Overview:
    Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3′ hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3, important second messengers that modulate the activity of downstream targets Akt and mTOR.{8039} Aberrant PI3K/Akt is associated with many human cancers. CAY10626 is a potent, dual PI3K?/mTOR inhibitor with IC50 values of 0.9 and 0.6 nM for the two respective kinases.{18031} In a tumor cell growth inhibition assay, CAY10626 demonstrates IC50 values of 50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3K? and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed.{18031}

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