CAY10505

CAY10505

CAT N°: 10009078
Price:

From 55.00 46.75

Phosphoinositide 3-kinase ? (PI3K?), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the ? isoform (IC50 = 30 nM) better than the ?, ?, and ? isoforms (IC50 = 0.94, 20, and 20 ?M, respectively).{14230} Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).{14230} Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3K?-deficient mice.{14230}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
  • Correlated keywords
    • phosphoinositide 3-kinase immunity autoimmune inflammation PI3K? PI3K? PI3K? PI3K? casein kinases 2 CK2 phosphorylation PKB/Akt macrophages neutrophil recruitment cancer PI3s T2Ds PI3Ks PI3K.gamma. PI3Kg
  • Product Overview:
    Phosphoinositide 3-kinase ? (PI3K?), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the ? isoform (IC50 = 30 nM) better than the ?, ?, and ? isoforms (IC50 = 0.94, 20, and 20 ?M, respectively).{14230} Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).{14230} Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3K?-deficient mice.{14230}

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