CAY10505

CAY10505

CAT N°: 10009078
Price:

From 55.00 46.75

Phosphoinositide 3-kinase ? (PI3K?), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the ? isoform (IC50 = 30 nM) better than the ?, ?, and ? isoforms (IC50 = 0.94, 20, and 20 ?M, respectively).{14230} Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).{14230} Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3K?-deficient mice.{14230}

We also advise you

TAF 10 Peptide

TAF 10 Peptide

TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...

€191.00
View