β-Catenin (Phospho-Ser33,37) Polyclonal Antibody

CAT N°: 10009180
Price:

640.00 544.00

?-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway.{14334,14336} The role of ?-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by glycogen synthase kinase 3? (GSK3?).{14335} This hyperphosphorylation promotes the ubiquitylation and targeted destruction of ?-catenin. Mutations in components of this phosphorylation-regulated process that prevent ?-catenin hyperphosphorylation by GSK3? are strongly associated with cancers.{14335,14336,14337}

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • antibodies proteins diseases antibodies antisera antiserum WB western blots blotting cadherin cells adhesion neural Wingless/Wnt signaling pathways hyperphosphorylation glycogen synthases kinases 3.beta. GSK3.beta. 3b cancers phospho-specific immunoblotting
  • Product Overview:
    ?-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway.{14334,14336} The role of ?-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37, and Thr41 by glycogen synthase kinase 3? (GSK3?).{14335} This hyperphosphorylation promotes the ubiquitylation and targeted destruction of ?-catenin. Mutations in components of this phosphorylation-regulated process that prevent ?-catenin hyperphosphorylation by GSK3? are strongly associated with cancers.{14335,14336,14337}

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