From €590.00 €501.50
Cardiotrophin-1 is a glycosylated polypeptide and member of the IL-6 family of cytokines.{61612} It is composed of four ?-helices but lacks the hydrophobic N-terminal secretion signal sequence that most IL-6 family proteins contain.{61613} Cardiotrophin-1 is primarily expressed in embryonic and adult cardiomyocytes, but it is also expressed in skeletal muscle, as well as the liver, lungs, and kidneys.{61612,61614} Its expression is increased under cellular stress conditions, such as hypoxic stress.{61612} Cardiotrophin-1 forms a heterocomplex with gp130 and leukemia inhibitory factor receptor ? (LIFR?) in cardiomyocytes and, in other cells, with gp130, LIFR?, and cytokine-specific ?-chains, which signal through the JAK/STAT, ERK/MAPK, and PI3K/AKT pathways. It induces cardiomyocyte hypertrophy in vitro, and levels of cardiotrophin-1 are increased in the heart in animal models after myocardial infarction and protect the heart from ischemic injury.{61612} Serum levels of cardiotrophin-1 are increased in patients with heart failure and hypertensive disease.{61613} It has both protective or detrimental effects in various tissues, including the heart, kidney, and vasculature.{61614,61612} Cayman’s Cardiotrophin-1 (human, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of cardiotrophin-1 (amino acids 2-201) fused to human IgG1 at its N-terminus, consists of 460 amino acids and has a calculated molecular weight of 49.5 kDa. As a result of glycosylation, the monomer migrates at approximately 54 kDa by SDS-PAGE under reducing conditions.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Custom code | 3504.00 |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Purity | ≥80% estimated by SDS-PAGE |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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