€579.00 €492.15
Cardiac troponin I (cTnI) is a subunit of the troponin complex in cardiac muscle thin filaments, which plays a role in muscle activity.{55210} It is encoded by TNNI3 in humans and is expressed exclusively in the heart. cTnI is a multidomain protein composed of an N-terminal domain, IT-arm, inhibitory domain, regulatory domain, and C-terminal mobile domain. The N-terminal domain is exclusive to cTnI and is essential to the interaction of cTnI with troponin C and in the regulation of calcium-dependent muscle contraction. cTnI binds to actin to hold the troponin complex in place in thin myofilaments. Phosphorylation of cTnI at serines 22 and 23 in the N-terminus decreases sarcomere calcium sensitivity, promotes calcium dissociation from troponin C, and enhances diastolic relaxation.{55219,55221} Cardiac systolic dysfunction in human and animal models of heart failure is linked to PKC phosphorylation of cTnI at serines 23, 24, 43, and 45, as well as threonine 144.{55221} Cayman’s Cardiac Troponin I Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes cTnI at approximately 25 kDa from human, mouse, and rat samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Fusion protein of the mouse cardiac troponin I holoprotein |
| Application(s) | WB |
| Formulation | 100 µl of unpurified neat serum polyclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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