Carboplatin-d<sub>4</sub>

Carboplatin-d4

CAT N°: 34506
Price:

330.00 280.50

Carboplatin-d4 is intended for use as an internal standard for the quantification of carboplatin (Item No. 13112) by GC- or LC-MS. Carboplatin is a platinum-containing DNA-crosslinking agent.{64047} It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).{24627,24628} Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.).{32401} Formulations containing carboplatin have been used in the treatment of ovarian cancer.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2-)-?O,?O??]-platinum-d4
  • Correlated keywords
    • Caromedac Carbosin CBDCA Cycloplatin JM8 NSC201345 NSC241240 Paraplat Paraplatin Ribocarbo GCMS LCMS deuterium deuterated GLC4 A 2780 SKOV 3 ADJ PC6
  • Product Overview:
    Carboplatin-d4 is intended for use as an internal standard for the quantification of carboplatin (Item No. 13112) by GC- or LC-MS. Carboplatin is a platinum-containing DNA-crosslinking agent.{64047} It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).{24627,24628} Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.).{32401} Formulations containing carboplatin have been used in the treatment of ovarian cancer.

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